Description
Indications for Acyclovir Inj:
Genital herpes (severe initial episodes in immunocompetent patients). Herpes simplex (in neonates, and as initial and recurrent treatment in immunocompromised patients). Herpes simplex encephalitis. Varicella zoster (immunocompromised patients).
Adult:
Give by IV infusion over 1 hour. Mucocutaneous herpes simplex (immunocompromised): 5mg/kg every 8 hours for 7 days. Genital herpes: 5mg/kg every 8 hours for 5 days. Encephalitis: 10mg/kg every 8 hours for 10 days. Varicella zoster (immunocompromised): 10mg/kg every 8 hours for 7 days. All: max 20mg/kg every 8 hours. Obese: dose based on ideal body weight. Renal impairment: CrCl 250mL/min: give dose every 12 hours; CrCl 10–25mL/min: give dose every 24 hours; CrCl<10mL/min: reduce dose by 50% and give every 24 hours. Coincide a dose for after hemodialysis.
Children:
Give by IV infusion over 1 hour. Neonatal (birth mos) herpes simplex: 10mg/kg every 8 hours for 10 days (doses of 20mg/kg every 8 hours have been used; see literature). Mucocutaneous herpes simplex (immunocompromised): 10mg/kg every 8 hours for 7 days. Encephalitis: 12yrs: 20mg/kg every 8 hours for 10 days. Varicella zoster: <12yrs (immunocompromised): 20mg/kg every 8 hours for 7 days. All: max 20mg/kg every 8 hours. Obese: dose based on ideal body weight. Renal impairment: CrCl 25 50mL/min: give dose every 12 hours; CrCl 10 25mL/min: give dose every 24 hours; CrCl <10mL/min: reduce dose by 50% and give dose every 24 hours. Coincide a dose for after hemodialysis.
Contraindications:
Valacyclovir hypersensitivity.
Warnings/Precautions:
Renal impairment: see literature. Maintain adequate hydration. Neurological or serious renal, hepatic, or electrolyte abnormalities, or significant hypoxia. Elderly. Pregnancy (Cat.B). Nursing mothers.
Interactions:
Avoid nephrotoxic drugs. Potentiated by probenecid.
Pharmacological Class:
Nucleoside analogue.
Adverse Reactions:
Inj site reactions, transient elevated BUN and serum creatinine, GI upset, pruritus, rash, CNS effects (esp. in elderly), elevated transaminases, hematologic abnormalities, renal failure, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in immunocompromised patients.
Storage Conditions: Store it at room temperature.
Key Feature:
- WHO-GMP Certified
- Packaging can be customize
- Hygienically packed
- Balanced composition
- Stability
- Highly effective